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Renal Disease and Electrolyte Course, Aspen, CO; July 23-27, 2018

HyperTension - Thu, 03/15/2018 - 09:08
University of Colorado: Registration: To register visit http://medschool.ucdenver.edu/cme or contact Pam Welker at (303)724-3551 or at pam.welker@ucdenver.edu
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USRDS Annual Report 2017

HyperTension - Mon, 03/12/2018 - 10:00
USRDS: US Renal Data System 2017 Annual Data Report: Epidemiology of Kidney Disease in the United States
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In ICU, Ringer's lactate also better than saline.

HyperTension - Wed, 02/28/2018 - 22:12
NEJM: Conclusions: Among critically ill adults, the use of balanced crystalloids for intravenous fluid administration resulted in a lower rate of the composite outcome of death from any cause, new renal-replacement therapy, or persistent renal dysfunction than the use of saline.
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Ringer's lactate causes less kidney injury than saline.

HyperTension - Wed, 02/28/2018 - 22:10
NEJM: Balanced crystalloids resulted in a lower incidence of major adverse kidney events within 30 days than saline (4.7% vs. 5.6%; adjusted odds ratio, 0.82; 95% CI, 0.70 to 0.95; P=0.01).
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Lp(a) in the news in the New York Times

HyperTension - Thu, 01/11/2018 - 22:26
NY Times (Anahad O'Connor): “Only a small percentage of physicians know about this,” she said. “The biggest challenge for patients is finding knowledgeable physicians who know about this and can help them.”
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Inhibitors of NMMT reduce obesity by increasing fat cell metabolism.

HyperTension - Tue, 01/09/2018 - 13:55
Biochem Pharmacol (Neelakantan et al): Research scientists at the University of Texas Medical Branch (UTMB) at Galveston say they developed a promising new drug that curbs obesity without dieting and, based upon preliminary study findings, they may be on their way to unleashing a breakthrough for the millions who struggle with their weight. "Treatment of diet-induced obese mice systemically with a potent NNMT inhibitor significantly reduced body weight and white adipose mass, decreased adipocyte size, and lowered plasma total cholesterol levels. Notably, administration of NNMT inhibitors did not impact total food intake nor produce any observable adverse effects."
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J-curve in BP studies is an artifact - similar to dose targeting bias in HEMO.

HyperTension - Thu, 01/04/2018 - 16:09
Circulation (Kalkman et al): Conclusions: Low on-treatment SBP levels are associated with increased cardiovascular events and all-cause mortality. This association is independent of the attained blood pressure level because the J curve aligns with the SBP target. Our results suggest that the benefit or risk associated with intensive blood pressure–lowering treatment can be established only via randomized clinical trials.
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